ࡱ>  Sbjbj 4eeJ  lh\Yb,+,Waaaaaaa,d7gxa-oooa$b$$$o. a$oa$$HNlQPv "O*a)b0YbOg$gTQ$QT Soooaa$oooYbgooooooooo :   Natalie Wendt Thiex, Ph.D., MPH Assistant Professor Department of Biology and Microbiology South ֱ State University SNP Box 2140D, Room 251A phone: 605-695-6293; 605-688-5874 Brookings, SD 57007 email: Natalie.Thiex@sdstate.edu Education 2008 University of Michigan, Ph.D., Toxicology Department of Environmental Health Sciences Development of a Gestational Membrane Transwell System For Measurement of Prostaglandin and Cytokine Responses Advisor: Rita Loch-Caruso, Ph.D. 2002 University of Michigan, M.P.H., Hospital & Molecular Epidemiology In vitro biodistribution of CTLA4Ig-conjugated liposomes as targets for B7 costimulatory molecules on antigen-presenting cells Concordia College, Moorhead, MN, B.A., Honors Biology, Chemistry (minor) summa cum laude Postdoctoral Training 2008-2012 Postdoctoral Research Fellow, E.A. Martin Program in Human Nutrition, South ֱ State University, Brookings, SD Advisor: Bonny Specker, Ph.D. Research Funding BioSNTR Faculty Member Annual funding ~$65,000/year Responsibilities: Manage BioSNTR flow cytometry core instrumentation, lead investigator on macrophage growth factor signaling, vesicular transport and lipid droplet biology. BioSNTR Summer Undergraduate Research Fellowship, Summer 2016 Fellow: H. Carson Eisenbeisz, $5000 stipend Mentor: Natalie W. Thiex SDSU Research/Scholarship Support Fund - Seroprevalence of Antibodies for the C/OK Influenza Virus in a Human Population from Eastern South ֱ Principal Investigator: Natalie W. Thiex, Co-investigator: Feng Li $6970 (direct) 4/07/14-3/31/15 Fishback Honors College Academic and Scholarly Excellence Fund Undergraduate Research Mentorship Investigation of a newly discovered influenza virus as a human pathogen Fellow: Alyssa Petersen Mentor: Natalie W. Thiex BioSNTR Summer Undergraduate Research Fellowship, Summer 2015 Fellow: Miriam Crinion, $5000 stipend Mentor: Natalie W. Thiex BioSNTR Summer Undergraduate Research Fellowship, Summer 2015 Fellow: Hana Abdeljalil, $5000 stipend Mentor: Natalie W. Thiex College of ABS Summer Research Mentorship Fellow: Kevin Parr, $1000 stipend, $1000 supplies Mentor: Natalie W. Thiex Memberships 2013-present Society for the Advancement of Biology Education Research 2013-present American Society of Cell Biology Professional Development Get Students to Focus on Learning Instead of Grades: Metacognition is the Key! Summer 2014 Approaches for Teaching Metacognitive Strategies to Individuals and Groups, Summer 2014 Assessment Strategies for the Flipped Classroom, South ֱ State University, Summer 2013 Flipping the Classroom Mini-conference, South ֱ State University, Spring 2013 Society for the Advancement of Biology Education Research National Conference, Minneapolis, MN, Summer 2013 Other Significant Contributions 2015 Chair, South ֱ Public Health Assoc. Annual Meeting, June 25-26, Sioux Falls, SD 2011-2015 Secretary & Executive Board Member, South ֱ Public Health Association 2010-2011 Committee Member, South ֱ State University Research and Scholarship Committee 2006-2007 Student Representative, Reproductive Sciences Program Executive Committee Winter 2005 Coordinator, Reproductive Sciences Program Seminar Series Winter 2004 Coordinator, Toxicology Seminar Series March 2004 Co-chair, Toxicology Symposium, Prenatal Origins of Adult Disease March 2003 Committee member, Toxicology Symposium, Toxicants as Tools 2001-2001 Student Representative, Curriculum Committee, Epidemiology Department Community Involvement 2010-2012 Board Member, Great After-school Place, Brookings, SD Peer-reviewed Publications Specker B, Thiex NW, Sudhagoni RG. Does Exercise Influence Pediatric Bone? A Systematic Review. Clin Orthop Relat Res. 2015 Nov; 473(11):3658-72. doi: 10.1007/s11999-015-4467-7 Wimberly A, and Thiex NW (2015). The Distance Women Travel Women and Healthcare in South ֱ. In Redlin, M., C. Stewart-Nunez and J. Barst, eds. Influence, Action and Voice: Contemporary South ֱ Women. SD Agricultural Museum Publications. Binkley, TL, Thiex NW, Specker B. Validation of Drinking Water Disinfection By-Product Exposure Assessment for the National Childrens Study. Journal of Exposure Science And Environmental Epidemiology. 2014 Jul 16. doi: 10.1038/jes.2014.51. PMID: 25027449 Thiex NW, Kalkwerf HJ, Specker BL (2010). Vitamin D Metabolism in Pregnancy and Lactation. In JW Pike, D Feldman and J Adams (eds.), Vitamin D (3rd ed.). Specker BL, Sudhagoni R, and Thiex NW (2010). Calcium Intake Influences the Bone Response to Exercise in Children. In J Anderson (ed.), Diet Nutrition and Bone. ThiexNW, ChamesMC, Loch-CarusoRK. Tissue-Specific Induction of COX-2 and Prostaglandins in Lipopolysaccharide-Stimulated Extraplacental Human Gestational Membranes in a 2-Chamber Transwell Culture System. Reproductive Sciences. 2010 Dec; 17(12):1120-9. PMCID: PMC3096444 ThiexNW, ChamesMC, Loch-CarusoRK. Tissue-specific cytokine release from human extra-placental membranes stimulated by lipopolysaccharide in a two-compartment tissue culture system. Reproductive Biology and Endocrinology2009, 7:117 (26 October 2009). PMCID: PMC2774314 Martin A, Beare T, Thiex NW, Holm RJ, Specker B. South ֱ's role in the National Children's Study. S D Med. 2009 Jun 62(6):245-7. PMID: 19650279 Park CG, Thiex NW, Lee KM, Szot GL, Bluestone JA, Lee KD. Targeting and blocking B7 costimulatory molecules on antigen-presenting cells using CTLA4Ig-conjugated liposomes: in vitro characterization and in vivo factors affecting biodistribution. Pharm Res. 2003 Aug; 20(8):1239-48. PMID: 12948022 Courses Taught BIOL 470/792 Cancer Biology BIOL 371 Genetics BIOS 792 Topics in Environmental Health, South ֱ State University BIOL 101 Biology Survey I, South ֱ State University CHEM 348L Biophysical Chemistry Laboratory, South ֱ State University CHEM 466 Biochemistry Laboratory, South ֱ State University Guest Lectures ECE/HDFS 227 Child Development, South ֱ State University Honors 303 The Work of Creativity, South ֱ State University ENVIRON 310 Toxicology: Environmental Chemicals and Disease, Univ of Michigan EPID 550 Reproductive Epidemiology, University of Michigan Poster Presentations Quantitative Analysis of Bisphenol A in Human Placentae from Nine Counties across the US: National Childrens Study (NCS). Alan Friedman, Michelle Friedman, Richard K Miller, Christopher Stodgell, Lisa Littman, Perry Sheffield, Philip Landrigan, Edward B. Clark, Michael Varner, Nancy Dole, Jennifer Culhane, James Swanson, Natalie Thiex, John Moye, National Childrens Study Placenta Consortium. International Federation of Placenta Associations Meeting. Submitted. Exploring the Biometal Composition of Human Placenta from the U.S. National Children's Study (NCS). Thomas Darrah, Richard K Miller, Christopher J Stodgell, Philip Landrigan, Edward B. Clark, Michael Varner, Nancy Dole, Jennifer Culhane, James Swanson, Natalie Thiex, John Moye, National Childrens Study Placenta Consortium. International Federation of Placenta Associations Meeting. Submitted. RNA Integrity Or Time To Collection Is Not correlated with Gene Expression Collected In The National Childrens Study (NCS). CJ Stodgell, RK Miller, L Salamone, TBusch, J Murray, Jia Chen, Luca Lambertini, Eric E. Schadt, Lisa Littman, Philip Landrigan, Kjersti Aagaard, Charlotte Hobbs, Edward B. Clark, Michael Varner, Nancy Dole, Jennifer Culhane, James Swanson, Natalie Thiex, Sarah Szabo, Maureen Durkin, Cheryl Walker, Carol Kasten, John Moye, National Childrens Study Placenta Consortium. International Federation of Placenta Associations Meeting. Submitted. Expression Quantitative Trait Loci in Placenta Tissues from the National Childrens Study Reveal Developmental Origins of Human Complex Diseases. Ke Hao, Antonio Di Narzo, Jia Chen, Eric E. Schadt, Lisa Littman, Philip Landrigan, Kjersti Aagaard, Charlotte Hobbs, Edward B. Clark, Michael Varner, Nancy Dole, Jennifer Culhane, James Swanson, Natalie Thiex, Jeffrey Murray, John Moye, Carol Kasten, Christopher J Stodgell, Richard K. Miller, National Childrens Study Placenta Consortium. International Federation of Placenta Associations Meeting. Submitted. Emerging and legacy environmental organic pollutants in placenta specimens collected in the National Childrens Study human placenta project. Priyanthi S. Dassanayake, Yulin Xia, Jessica Nanes, Prabha Ranasinghe, An Li, Christopher J. Stodgell, Edward B. Clark, Michael Varner, Philip Landrigan, Nancy Dole, Jennifer Culhane, Natalie Thiex, James Swanson, John Moye, Richard K. Miller, on behalf of National Childrens Study Placenta Consortium. BFR 2014 Meeting. Submitted. Direct Determination of BPA, BPA Glucuronide, BPA Sulfate, and BPS in Human Urine. Gerona, Roy; Schecter, Arnold J.; Friesen, Matthew; Cherry, Debra; Thiex, Natalie; Shropshire, William C.; Moye, John. Society of Toxicology Annual Meeting, March 2014. Serial Measurements of BPA and BPS in Texas Mother-infant Pairs from the 3rd Trimester of Pregnancy through the 4th Month of Lactation. Arnold Schecter, Cherry, D, Chunyang L., SY Yun and Kannan, K., Moye, J., Thiex, N., Shropshire W., and Birnbaum, L. Society of Toxicology Annual Meeting, March 2014. MCSF Receptor Endocytosis is Coupled to MAPK/ERK Activation in Bone Marrow Derived Macrophages. Natalie W. Thiex, Shalini T. Low-Nam, Jieqiong Lou, Lu Huang, Jason G. Kerkvliet, and Adam D. Hoppe. American Society for Cell Biology Annual Meeting, Dec. 2013. MCSF Receptor Endocytosis is Coupled to MAPK/ERK Activation in Bone Marrow Derived Macrophages. Natalie W. Thiex, Shuangling Zhang, Shalini T. Low-Nam, and Adam D. Hoppe. Sanford-SDSU Research Symposium, Dec. 2013. Understanding the Trace Metal Composition of Human Placenta from the National Childrens Study (NCS). Darrah TH, White AM, Campbell ME, Miller RK, Stodgell CJ, Katzman PJ, Ruffolo L, Weidenborner P, Culhane J, Wadlinger S, Landrigan P, Littman L, Thiex N, Specker B, Swanson J, Dole N, Eucker B, Clark EB, Varner M, Taggart E, Moye J. Birth Defects Research A 97: 332, 2013. Gene Expression in Human Placenta from the National Childrens Study (NCS) Stodgell CJ, Salamone L, Katzman PK, Ruffolo LI, Murray J, Busch T, Culhane J, Wadlinger S, Landrigan P, Littman L, Thiex N, Specker B, Swanson J, Dole N, Eucker B, Clark EB, Varner M, Taggart E, Moye J, Miller RK. Birth Defects Research A 97: 331, 2013. Use of the Human Placenta As a Biomarker for Environmental Exposures and Clinical, Genetics/Epigenetic, Morphological, and Systems Biology Assessments in the National Childrens Study (NCS). The National Childrens Study Placental Research Consortium, Miller RK, Stodgell CJ, Katzman PJ, Friedman AE, Jamerson D, Friedman MR, Salamone L, Ruffolo L, Weidenborner P, Aagaard-Tillery K, Culhane J, Wadlinger S, Pacholski M, Kent MA, Green L, Wapner R, Torres C, Perou J, Landrigan P, Chen J, Lambertini L, Littman L, Sheffield P, Golden A, Gilbert J, Lendor C, Allen S, Schadt E, Dudley J, Leuthner S, Szabo S, Salafia CM, Dalton JL, Misra D, Thiex N, Gutzman K, Martin A, Specker B, Hobbs C, MacCleod S, Walker CK, Swanson J, Holliday C, Butler J, LI A, Dassanayake RMAPS, Nanes J, Xia Y, Murray JC, Busch TD, Rigdon J, Darrah TH, Campbell E, Dole N, Thorp J, Eucker B, Bell C, Clark EB, Varner MW, Taggart E, Billy J, Stradling S, Leavitt J, Bell W, Waterfall S, OBrien B, Layton M, Todd D, Wilson K, Durkin MS, Sandoval M-N, Kasten C, Moye J Birth Defects Research A 97: 330, 2013. The Chorionic Surface Vascular Network in Human Placenta: Quantifying Structure to Estimate Gestational Stressors and Life Course Risks, Autism Spectrum Disorder (ASD) As a Model for Future Analyses: National Childrens Study and EARLI. Salafia CM, Dalton JL, Misra D, Stodgell CJ, Katzman PJ, Ruffolo LI, Culhane J, Wadlinger S, Torres C, Landrigan P, Littman L, Sheffield P, Leuthner S, Szabo S, Thiex N, Specker B, Swanson J, Dole N, Thorp J, Eucker B, Clark EB, Varner MW, Taggart E, Durkin MS, Sandoval M-N, Moye J, Miller RK. Birth Defects Research A 97: 333, 2013. Polybrominated Dephenyl Ethers in Mothers and Children from a U.S. National Childrens Study Formative Project. Schecter A, Cherry D, Thiex NW, Kannan K, Yun SH, Wang L, Hynan L, Cheng D, Hommel M, Imran N, Moye J, Birnbaum L. Society of Toxicology Annual Meeting, June 2012. Prenatal and postnatal exposure assessment of BPA and PBDEs in NCS mother and child participants. Natalie W. Thiex, Bonny L. Specker, Howard Wey, Ann Martin, Debra Cherry, and Arnold Schecter. Teratology Society Annual Meeting, June 2012. Measuring placentas: A comparison of the National Collaborative Perinatal Project and the National Childrens Study, 50 years of progress. (Long list of authors.) Teratology Society Annual Meeting, June 2012. Cost-Effective, Reproducible, and Reliable Automated Diagnosis of Intraamniotic Infection for Population Based Research from Placentae in the National Childrens Study. (Long list of authors.) Teratology Society Annual Meeting, June 2012. How to Slice the Placental Disk - One-Protocol-Fits-All or a Specimen-Specific Approach? (Long list of authors.) Teratology Society Annual Meeting, June 2012. Fresh Versus Formalin Fixed Human Placentae: Does Preservation Affect Chorionic Plate Measures? (Long list of authors.) Teratology Society Annual Meeting, June 2012. The Chorionic Surface Vascular Network in Human Placentae: What can be Measured and Does It Matter? (Long list of authors.) Teratology Society Annual Meeting, June 2012. Field Experience: Use of the Human Placenta as a Biomarker for Environmental Exposures, Epigenetic and Morphological Assessments in the National Childrens Study (NCS). (Long list of authors.) Teratology Society Annual Meeting, June 2012. New Vistas for Landscape Ecology: The Influences of Landscape Structure on Population Health. Michael C. Wimberly, Aki Michimi, Brittany Kleinsasser, Natalie W. Thiex, Jessica R. Meendering. International Association for Landscape Ecology, April 2012. Combination of Personal GPS Monitoring and Accelerometry to Assess Intensity and Location of Physical Activity in Preschoolers Brittany A. Kleinsasser, Natalie W. Thiex, Jessica R. Meendering, Bonny L. Specker and Michael C. Wimberly. SDSU/Avera Research Day, Sioux Falls, SD, Sept 2012. National Childrens Study Placenta Project 15 Institution Investigation. National Childrens Study Steering Committee Meeting, Bethesda, MD, February 2011. Instrument and Methods Testing and Evaluation for Measurement of Physical Activity in Toddlers. Natalie W. Thiex, Michael C. Wimberly, Jessica Meendering, Brittany Kleinsasser and Bonny L. Specker. National Childrens Study Steering Committee Meeting, Bethesda, MD, February 2011. Measurement of inflammation-stimulated prostaglandins from human gestational membranes. Natalie W. Thiex, Sarah R. Thiel and Rita Loch Caruso. Toxicology Symposium, University of Michigan, Ann Arbor, MI, April 2007. Measurement of inflammation-stimulated prostaglandins from human gestational membranes. Natalie W. Thiex, Sarah R. Thiel and Rita Loch Caruso. Society of Gynecologic Investigation, Reno, NV, March 2007. Secretion of uterotonic prostaglandins from human gestational membranes. Natalie W. Thiex and Rita Loch Caruso. Michigan Society of Toxicology, East Lansing, MI, March 2006. Prostaglandin compartmentalization in gestational membranes Sarah R. Thiel, Natalie W. Thiex and Rita Loch Caruso. Michigan Society of Toxicology Meeting, East Lansing, MI, November 2006. Secretion of uterotonic prostaglandins from intact human gestational membranes. Natalie W. Thiex and Rita Loch Caruso. RSP Poster Day, University of Michigan, Ann Arbor, MI, Sept 2006.  PCBs and TNF Cause Secretion of Uterotonic Prostaglandins from Intact Human Gestational Membranes Natalie W. Thiex and Rita Loch Caruso. Toxicology Symposium, University of Michigan, Ann Arbor, MI, March 2006. Polybrominated Diphenyl Ethers Stimulate the Release of Pro-inflammatory Cytokines from Term Human Gestational Membranes. Kelly A Brant, Natalie Thiex and Rita Loch Caruso. Society of Toxicology. San Diego, CA, March 2006. Decline in 15-hydroxy prostaglandin dehydrogenase activity in human placental and chorionic cells exposed to polychlorinated biphenyls. Natalie W. Thiex and Rita Loch Caruso. Toxicology Symposium, University of Michigan, Ann Arbor, MI, March 2005. Effects of persistent environmental toxicants on the prostaglandin synthetic and metabolic pathways and parturition. Natalie W. Thiex and Rita Loch Caruso. Toxicology Symposium, University of Michigan, Ann Arbor, MI, March 2004. Liposomal targeting to dendritic cells. Natalie W. Thiex and Kyung-Dall Lee. American Association of Pharmaceutical Scientists, Indianapolis, Indiana, Oct 2000. Oral Presentations National Childrens Study Formative Research Projects. Continuing Medical Education Seminar, Brookings Health System, Brookings SD, April 2011. Childbirth Options: Challenges to Midwifery in South ֱ. Women and Challenge Biennial Women's Research, Scholarship and Creative Activity Conference, University of South ֱ, Vermillion SD, March 2011. Analysis of PBDEs and BPA in breast milk, blood and urine. National Childrens Study Formative Research Project Update, South ֱ State University, Brookings, SD, January 2011. Childrens Activity Methods. Nutrition and Environmental Health Seminar Series. South ֱ State University, Brookings, SD, Nov 2009. The National Childrens Study. Life Science Seminar Series, South ֱ State University, Brookings, SD, Oct 2009. Childrens Activity Methods. National Childrens Study Administrative Meeting and Seminar Series. South ֱ State University, Brookings, SD, May 2009. Toxicants disrupt prostaglandin metabolism in human gestational membranes Environmental Health Sciences Seminar Series, University of Michigan, Ann Arbor, MI, Jan 2007. Toxicants disrupt prostaglandin metabolism in human gestational membranes Reproductive Sciences Program Seminar Series, University of Michigan, Ann Arbor, MI, Feb 2007. Effects of persistent organic toxicants on gestational membrane prostaglandin production. Environmental Health Sciences Seminar Series, University of Michigan, Ann Arbor, MI, Dec 2005. Effects of persistent organic toxicants on gestational membrane prostaglandin production. 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